I have this exact same problem, exiting from VR after using Navigraph in game panel and PMDG for more than 10min result in an instant CTD with a GPU error message! so much so that I ended up uninstalling the ingame panel knowing that it was the single unique feature that made me buy a subscription -I’m a VR only user-
dx12, RTX4090, Ryzen 7 5800x3D, 32GB RAM DDR4, 2TB NVME SSD Samsunng 980 Pro, Oculus Quest 2